Skip to content

Medical Aesthetics (Anti-Wrinkle Injections and Fillers)

Botulinum toxin for expression lines, hyaluronic acid fillers for volume loss and facial fat grafting: who they suit, how long they last and what the risks are.

What is it and how is it done?

Facial lines have two main causes, and the choice of treatment rests on telling them apart. Forehead lines, the vertical frown lines between the eyebrows and crow's feet at the outer corners of the eyes form through years of repeated movement of the facial muscles. With age, the fat and bony support of the cheeks, temples and under-eye area also diminish; the face loses volume, the nasolabial folds deepen and the under-eye area becomes hollow. Softening a line caused by movement calls for a different treatment from restoring lost volume.

Botulinum toxin (Botox)

Botulinum toxin temporarily reduces the nerve signal to a muscle and so softens its contraction. Its effect usually begins within 2–5 days, settles at about 2 weeks and lasts 3–4 months in most people. The aim is not a frozen face but softer lines with natural expression preserved. Botulinum toxin does not fully erase deep lines that are visible at rest, does not lift sagging skin and does not replace lost volume.

Hyaluronic acid fillers

Hyaluronic acid filler is a gel similar to a substance found naturally in the skin. It is used to restore lost volume or define contours in the cheeks, temples, under-eye area, nasolabial folds, lips, chin and jawline. The effect is visible immediately, and depending on the area the body gradually absorbs the filler, usually over 6–18 months. An important safety feature is that it can be dissolved, if needed, with an enzyme called hyaluronidase.

Facial fat grafting (lipofilling)

In facial fat grafting (lipofilling), fat is taken with fine cannulas from areas such as the abdomen or thighs, processed and placed in small amounts where volume has been lost. Because it is the patient's own tissue, it contains no foreign material, and fat that takes stays for a long time; some of the fat is absorbed in the first months, however, and a second session is sometimes needed. The procedure is usually done under sedation or general anaesthesia. An article by Prof. Dr. İlker Yazıcı describing a fat collection system for small-volume fat injections was published in Aesthetic Plastic Surgery in 2008.

A rare but important risk of fillers is that the product enters a blood vessel or compresses it from outside (vascular occlusion). This can lead to blanching or bluish discolouration of the skin, severe pain and, if untreated, tissue loss; very rarely, loss of vision has been reported. It is therefore important that fillers are given by a doctor who knows the course of the facial blood vessels and that the dissolving enzyme is ready for emergencies. At the consultation in Nişantaşı, Prof. Dr. İlker Yazıcı assesses the face at rest and in motion; where useful, volume differences are reviewed together with a 3D facial imaging and simulation system. If there is marked sagging, excess eyelid skin or under-eye bags, surgical options are also discussed openly.

What are the aims?

  • To soften forehead lines, frown lines and crow's feet caused by muscle movement while preserving expression.
  • To restore lost volume in the cheeks, temples and under-eye area so that the face looks more rested.
  • To balance the proportions of the lips, chin and jawline.
  • To achieve a limited, controlled change without altering the natural expression of the face.
  • For suitable people, to offer an option that postpones or complements surgery.

Who is it suitable for?

  • People with forehead lines, frown lines or crow's feet that become more visible with facial expression
  • People with volume loss in the cheeks, temples or under the eyes, or with deepened nasolabial folds
  • People bothered by a mild imbalance of the lips, chin or jawline
  • People who do not want surgery, or do not yet need it, and expect a limited change
  • People who accept that the effect is temporary and needs repeating at intervals
  • Adults aged 18 or over in good general health with realistic expectations

When is it postponed or not recommended?

  • Pregnancy and breastfeeding
  • Active infection, cold sores or inflamed acne in the treatment area
  • Neuromuscular disorders such as myasthenia gravis (for botulinum toxin)
  • Known allergy to an ingredient of the product, or a previous serious reaction to a filler
  • Conditions that only surgery can correct, such as marked skin laxity or excess eyelid skin

Alternatives

Facelift and neck lift
For marked sagging, surgery that repositions the skin and underlying tissues can achieve a change that injections cannot; recovery takes longer.
Eyelid surgery and brow lift
If there is excess upper eyelid skin, under-eye bags or a low brow, surgery may be the more suitable option.
Skin care and sun protection
Regular sunscreen and appropriate skin care help preserve skin quality and limit fine lines; on their own they do not correct deep lines or volume loss.
Dermatological skin resurfacing
Methods such as chemical peels or laser treatment can be used by a dermatologist for fine lines and pigmentation on the skin surface.

The process step by step

  1. 1

    First contact

    You can send photos of your face from the front and side, at rest and with expression, and a short description of your expectations by WhatsApp or e-mail, or call the practice. This information gives you a general idea of the options and helps plan the examination; the medical assessment and the decision take place at the examination in Nişantaşı.

  2. 2

    Consultation and facial analysis

    At the practice in Nişantaşı, facial expressions, volume loss and skin quality are assessed; you are asked about medications, allergies and any previous fillers. The plan and risks are explained.

  3. 3

    Treatment

    The skin is cleansed and, if needed, an anaesthetic cream is applied; the toxin or filler is injected with a fine needle or cannula. Facial fat grafting is performed in an operating theatre.

  4. 4

    Aftercare instructions

    Cold compresses and what to watch for on the first day are explained. If you experience unusual or severe pain, marked blanching or grey or blue discolouration around the injection site, or any change in vision during or after filler treatment, seek medical help immediately. For any change in vision, go to an emergency department immediately. Do not wait for a message or callback from the clinic; also inform the treating doctor without delaying emergency assessment.

  5. 5

    Review and repeat plan

    A review takes place about 2 weeks after botulinum toxin and 2–4 weeks after filler; minor adjustments and the timing of the next treatment are planned together if needed.

Recovery timeline

  1. First hours

    Redness and small bumps may appear at the injection points. After botulinum toxin, it is advised not to massage the area or lie down for the first few hours.

  2. Days 1–3

    After filler, swelling can be noticeable, especially in the lips, and bruising may develop. Avoiding intense exercise, saunas and alcohol for a short time is advised. Expected temporary swelling and bruising should not be confused with unusual pain or a change in vision. If you experience unusual or severe pain, marked blanching or grey or blue discolouration around the injection site, or any change in vision during or after filler treatment, seek medical help immediately. For any change in vision, go to an emergency department immediately. Do not wait for a message or callback from the clinic; also inform the treating doctor without delaying emergency assessment.

  3. Days 2–5

    The effect of botulinum toxin begins; swelling and bruises start to fade.

  4. Week 2

    The toxin effect settles and a review takes place; the final shape of the filler is assessed. After fat grafting, most of the swelling has gone down.

  5. Months 3–6

    The toxin effect begins to wear off, and the treatment can be repeated if desired. After fat grafting, the lasting volume of the fat that has taken becomes apparent.

  6. Months 6–18

    Hyaluronic acid filler is gradually absorbed, depending on the area; whether a top-up is needed is assessed together.

Risks and possible complications

Every surgical procedure carries risks. Your personal risk is assessed in detail at the consultation.

  • Redness, swelling, bruising and tenderness at the injection points
  • Temporary drooping of the eyelid or eyebrow, asymmetry and headache after botulinum toxin; these usually resolve within a few weeks
  • Irregularities, palpable lumps (nodules) or a bluish tint in thin skin after filler
  • Infection and delayed inflammatory reactions that can appear weeks or months later
  • Vascular occlusion: blanching or bluish discolouration of the skin, severe pain and tissue loss; this requires emergency treatment. If you experience unusual or severe pain, marked blanching or grey or blue discolouration around the injection site, or any change in vision during or after filler treatment, seek medical help immediately. For any change in vision, go to an emergency department immediately. Do not wait for a message or callback from the clinic; also inform the treating doctor without delaying emergency assessment.
  • Very rarely, loss of vision or stroke caused by vascular occlusion after filler or fat injection
  • With fat grafting, absorption of part of the fat, irregularities or overcorrection, and the need for an additional session
  • Allergic reactions (rare)
  • A result that looks unnatural or does not meet expectations

What determines the cost?

The fee for medical aesthetic treatments depends on the type of treatment, the number of areas treated, the amount of product needed and the characteristics of the product. Facial fat grafting is assessed differently, because it involves additional items such as the operating theatre, anaesthesia and the area from which the fat is taken.

Once the treatments you need and the approximate amount of product have been determined at the consultation, you receive a written, itemised quote that states what is included. How a small additional treatment at the review appointment will be handled is also explained in advance. As cosmetic treatments, these are generally not covered by health insurance.

If you are coming to Istanbul

If you are travelling from abroad, botulinum toxin and filler treatments can often be done on the same day as the consultation, and you can usually travel home the same day; because of possible swelling and bruising, schedule them at least 2 weeks before an important event. A review is planned about 2 weeks after toxin treatment; back home, you stay in touch with the practice by sending photos and messages, and if something needs to be examined, a check-up in Istanbul or a visit to a local doctor is arranged. For facial fat grafting, a stay of 2–3 days in Istanbul is usually enough. The practice is authorised by the Turkish Ministry of Health for international health tourism (certificate no. ST-2365); help with accommodation near the clinic and airport transfer can be arranged through authorised partners.

Frequently asked questions

What is the difference between anti-wrinkle injections and fillers?

Botulinum toxin injections (often called anti-wrinkle injections) and hyaluronic acid fillers address different problems. Botulinum toxin temporarily softens muscle contraction and reduces expression lines on the forehead, between the eyebrows and around the eyes. Fillers restore lost volume in areas such as the cheeks, temples, under-eye area or lips and fill deep lines. Many people need both, and where appropriate they can be given in the same session.

When do anti-wrinkle injections start to work, and how long do they last?

The effect of botulinum toxin usually begins within 2–5 days and settles at about 2 weeks. In most people it lasts 3–4 months, after which muscle movement gradually returns. How long it lasts depends on the area treated, muscle strength and the individual. When the effect wears off, the face returns to how it was before treatment, with no lasting change. The result is assessed at a review about 2 weeks after treatment, and a small additional treatment is given if needed.

How long does hyaluronic acid filler last, and can it be dissolved?

Hyaluronic acid filler is gradually absorbed by the body, usually over 6–18 months depending on the area and the density of the product. It tends to last a shorter time in mobile areas such as the lips and longer in areas such as the cheeks and chin. Hyaluronic acid filler can be dissolved with an enzyme called hyaluronidase; this matters both for correcting an unwanted shape and in emergencies such as vascular occlusion. Permanent fillers that cannot be reversed are not recommended.

Are fillers dangerous, and what is vascular occlusion?

Most filler treatments result only in short-lived swelling and bruising. A rare but important risk is that the filler enters a blood vessel or compresses it. This causes blanching or bluish discolouration of the skin and severe pain; if not treated quickly, it can lead to tissue loss and, very rarely, loss of vision. Fillers should therefore be given by a doctor who knows the course of the facial blood vessels, with the dissolving enzyme kept ready for emergencies. If you experience unusual or severe pain, marked blanching or grey or blue discolouration around the injection site, or any change in vision during or after filler treatment, seek medical help immediately. For any change in vision, go to an emergency department immediately. Do not wait for a message or callback from the clinic; also inform the treating doctor without delaying emergency assessment.

Do anti-wrinkle injections and fillers hurt, and can I go back to work the same day?

Botulinum toxin is injected with very fine needles and usually causes only a brief pinprick sensation. An anaesthetic cream is used before filler treatment, and many filler products also contain a local anaesthetic. Most people return to work and social life immediately after treatment. Redness at the injection points fades within a few hours, while bruising and swelling can last a few days. For this reason, schedule treatment at least 2 weeks before an important event.

Who is facial fat grafting for, and how does it differ from fillers?

Facial fat grafting (lipofilling) suits people with more extensive volume loss in the cheeks, temples or around the eyes who prefer their own tissue; it can also be combined with a facelift. Fat is taken from the abdomen or thighs with fine cannulas and placed in the face in small amounts. Fat that takes stays for a long time, but as some is absorbed, a second session may be needed. Unlike fillers, it requires sedation, swelling lasts 1–2 weeks and entry scars a few millimetres long remain.

At what age can anti-wrinkle injections and fillers be done, and who should not have them?

Cosmetic botulinum toxin and filler treatments are given to people aged 18 and over. There is no set starting age; the decision is based on the need seen at the examination, not on age. Treatment is not given during pregnancy or breastfeeding, when there is an infection or cold sore in the treatment area, in neuromuscular disorders such as myasthenia gravis, or with an allergy to the product. Any previous fillers, especially permanent ones, must be mentioned at the consultation.

When is surgery more suitable than anti-wrinkle injections or fillers?

Injections help with volume loss and problems related to muscle movement, but they do not lift sagging skin or remove excess skin. If there is marked sagging of the cheeks and neck, excess upper eyelid skin, prominent under-eye bags or a low brow, a facelift, eyelid surgery or a brow lift may be more suitable. In these situations, using filler alone can make the face look heavy and unnatural. Both options are discussed openly at the consultation.

What determines the cost of anti-wrinkle injections and fillers?

The fee for medical aesthetic treatments depends on the type of treatment, the number of areas treated, the amount of product needed and the characteristics of the product. Facial fat grafting is assessed separately because it requires an operating theatre and anaesthesia. Once the need and the approximate amount of product have been determined at the consultation, you receive a written, itemised quote. As cosmetic treatments, these are generally not covered by health insurance.

Should I stop blood thinners, supplements or smoking before treatment?

Aspirin, blood thinners, fish oil and some herbal supplements can increase the risk of bruising. Prescription medications should not be stopped on your own; if needed, the decision is made together with the prescribing doctor. Smoking can reduce how well fat takes, especially with fat grafting, and slows healing. Avoiding intense exercise, saunas and alcohol on the first day after treatment is advised. All medications you take and any allergies should be mentioned at the consultation.

Last updated: · Responsible for content: Prof. Dr. İlker Yazıcı

Book a consultation for Medical Aesthetics

Send your questions and photos via WhatsApp, or call to arrange a consultation date.